ALL CATEGORIES

Home RESEARCH CHEMICALS Buy 5-MeO-DMT Powder Online

Buy 5-MeO-DMT Powder Online

$315.00$1,850.00

5-MeO-DMT is a naturally-occurring hallucinogenic indolealkylamine that potently activates serotonin receptors.Buy 5-MeO-DMT Powder Online

Clear

Description

Buy 5-MeO-DMT Powder Online

5-MeO-DMT is a naturally-occurring hallucinogenic indolealkylamine that potently activates serotonin receptors.Although this compound is regulated in many countries, including the United States, it has been described as an ‘emerging psychoactive substance’ found in party pills and related mixtures.As 5-methoxy DMT is inactivated by monoamine oxidases, inhibitors of monoamine oxidases are often combined with 5-methoxy DMT to prolong its activity,The pharmacological and toxicological properties of this compound have been recently reviewed.This product is intended for forensic applications.Contact us for more details.Several scientific experimental studies have tried to measure subjective experiences of altered states of consciousness induced by drugs under highly controlled and safe conditions.In the 1990s, Rick Strassman and his colleagues conducted a five-year-long DMT study at the University of New Mexico.The results provided insight about the quality of subjective psychedelic experiences. In this study participants received the DMT dosage intravenously via injection and the findings suggested that different psychedelic experiences can occur, depending on the level of dosage. Lower doses (0.01 and 0.05 mg/kg) produced somaesthetic and emotional responses, but not hallucinogenic experiences (e.g., 0.05 mg/kg had mild mood elevating and calming properties).In contrast, responses produced by higher doses (0.2 and 0.4 mg/kg) researchers labeled as “hallucinogenic” that elicited “intensely colored, rapidly moving display of visual images, formed, abstract or both”. Comparing to other sensory modalities the most affected was visual domain. Participants reported visual hallucinations, less auditory hallucinations and specific physical sensation progressing to a sense of bodily dissociation, as well as experiences of euphoria, calm, fear, and anxiety.Desmethylprodine was first synthesized in 1947 at Hoffman-LaRoche Laboratories by Albert Ziering and John Lee. They found that it produced effects similar to morphine when administered to rats.Ziering had been searching for synthetic painkillers that were less addictive than morphine. The new drug was a slight variant of pethidine. It was found to be no more effective than pethidine and was never marketed.This research produced the analgesic alphaprodine (Nisentil, Prisilidine), a very closely related compound.In 1976, a 23-year-old graduate student in chemistry named Barry Kidston was searching for a way to make a legal recreational drug. Having read the paper by Ziering and Lee, he deduced that he could make a drug with pethidine’s effects without its legal restrictions, since desmethylprodine is a different molecule and had never been addressed by law. Kidston successfully synthesized and used desmethylprodine for several months, after which he suddenly came down with the symptoms of Parkinson’s disease and was hospitalized. Physicians were perplexed, since Parkinson’s disease would be a great rarity in someone so young, but L-dopa, the standard drug for Parkinson’s, relieved his symptoms. L-dopa is a precursor for dopamine, the neurotransmitter whose lack produces Parkinson’s symptoms. It was later found that his development of Parkinson’s was due to a common impurity in the synthesis of MPPP called MPTP (1-methyl-4 phenyl-1,2,3,6-tetrahydropyridine), a neurotoxin that specifically targets dopamine producing neurons.In the United States, MPPP is now in Schedule I of the Controlled Substances Act with a zero aggregate manufacturing quota as of 2014. The free base conversion ratio for salts includes 0.87 for the hydrochloride. It is listed under the Single Convention on Narcotic Drugs and is controlled in most countries in the same fashion as is morphine.The intermediate tertiary alcohol is liable to dehydration in acidic conditions if the reaction temperature rises above 30 °C. Kidston did not realize this and esterified the intermediate with propionic anhydride at an elevated temperature. Consequently, MPTP was formed as a major impurity.1-Methyl-4-phenylpyridinium (MPP+), a metabolite of MPTP, causes rapid onset of irreversible symptoms similar to Parkinson’s disease.MPTP is metabolized to the neurotoxin MPP+ by the enzyme MAO-B, which is expressed in glial cells. This selectively kills brain tissue in the area of the brain called the substantia nigra and causes permanent Parkinsonian symptoms.Buy 5-MeO-DMT Powder Online

Reviews

There are no reviews yet.

Be the first to review “Buy 5-MeO-DMT Powder Online”

Your email address will not be published. Required fields are marked *

error: Content is protected !!